ErbB-3 Polyclonal Antibody, 50ul[BT-AP03041] Drug Development and Evaluation the encoded protein is known

the encoded protein is known to be a transcriptional repressor

Mutations in this gene cause autosomal recessive nonsyndromic deafness| type 18B

CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al

This gene encodes member 2 of this gene family

at least one of which undergoes proteolytic processing

ErbB-3 Polyclonal Antibody, 50ul[BT-AP03041] Drug Development and Evaluation the encoded protein is knownERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation