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B23 Polyclonal Antibody, 50ul Drug Development and Evaluation Alternative splicing of this gene

SKU: 17885436005

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B23 Polyclonal Antibody, 50ul Drug Development and Evaluation Alternative splicing of this geneNPM1 encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of NPM1 have been identified.

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Description

Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms

This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin

Alternate transcriptional splice variants

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells

but they have not been fully described

B23 Polyclonal Antibody, 50ul Drug Development and Evaluation Alternative splicing of this geneNPM1 encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of NPM1 have been identified.

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