Presenilin 1 Polyclonal Antibody, 50ul Biomatrix This gene encodes both membrane-bound

This gene encodes both membrane-bound and secreted protein isoforms

which form mobile hydrophobic regions bounded by crosslinks between lysine residues

This protein may also function as a tumor suppressor in some cancers

GPR158 (G Protein-Coupled Receptor 158) is a Protein Coding gene

Alternatively spliced transcript variants encoding different isoforms have been described for GFRA4

Presenilin 1 Polyclonal Antibody, 50ul Biomatrix This gene encodes both membrane-boundAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.