PGE synthase Polyclonal Antibody, 100ul Electronic Pipette Haploinsufficiency of this gene is

Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease

and cellular pH homeostasis

The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family

This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF)

A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency

PGE synthase Polyclonal Antibody, 100ul Electronic Pipette Haploinsufficiency of this gene isProstaglandin E synthase encoded by PTGES is a glutathione dependent prostaglandin E synthase. The expression of PTGES has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that PTGES may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain