Cortactin Monoclonal Antibody, 100ul RNA Synthesis Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding different proteins have been described

a melanocyte-specific protein

Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS)

The protein described here lacks consensus sequences for N-glycosylation present in other granzymes

YEATS4 has been shown to be amplified in tumors

Cortactin Monoclonal Antibody, 100ul RNA Synthesis Alternatively spliced transcript variants encodingThis gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase