CD6 Polyclonal Antibody, 50ul[BT-AP01936] Custom RNA Oligos Certain mutations in this gene

Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia

and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system

Overexpression increases MET activation and promotes invasive growth

It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP

Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex

CD6 Polyclonal Antibody, 50ul[BT-AP01936] Custom RNA Oligos Certain mutations in this geneThe protein encoded by ITIH4 is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.