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Some patients, particularly young or middle-aged women, may become obese on this energy intake or may refuse to ingest the recommended calories out of fear of obesity

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In contrast, weight loss improves muscle insulin sensitivity, which, in turn, helps prevent muscle protein breakdown

In the secondary endpoint, subjects treated with tirzepatide achieved an overall mean weight loss of 26.6% after 12 weeks of intensive lifestyle intervention followed by 72 weeks of tirzepatide treatment

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