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Most patients experience a full return to function and significantly reduced pain levels

Methods Considering the critical role of macrophages in HFD-induced obesity and inflammation, we generated mice with a macrophage-specific Grn depletion ( Grn -MKO mice) by mating lysozyme M (LysM)-Cre and Grn -floxed mice

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For 15+ years, they were primarily used to help manage blood sugar levels in patients with type 2 diabetes