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In addition to a decrease in A42 in extracellular vesicles (EV), compared to placebo, exenatide showed no significant difference or trend in cognitive function, MRI cortical thickness, volume, or biomarkers in cerebrospinal fluid, plasma, or EVs (Mullins et al., 2019)

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Therefore, therapeutic options that could work in a way other than classic antidepressants are being sought to increase the effectiveness of the treatment

Most patients begin experiencing appetite suppression within the first week, with many reporting reduced hunger as early as day 3 of their first dose