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Name: does tirzepatide work better than semaglutide for weight loss vs. https://bit.ly/4uDVQAe Compare GLP-1 Options | Ozempic
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10.1136/jech-2019-212268 J Epidemiol Community Health

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Because this was apparent following acute and steady-state administration, differences in plasma half-lives alone do not explain this difference

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Measurements were taken at baseline prior to consuming the product and at 75 min

Native GLP-1 remains in the bloodstream for only a few minutes, so alterations to the molecule (amino acid changes or side chain additions) are required to make it resistant to the effect of dipeptidyl peptidase-4 (1,2)