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These effects include modulation of dopaminergic and serotonergic systems, reduction of gut permeability, and a clear reduction in systemic inflammation

Koselugo (selumetinib) is just the first step, with many more drugs in the pipeline for all manifestations of NF, which need funding to be tested in preclinical and clinical trials

doi: 10.36948/ijfmr.2023.v05i04.5842 37