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Yu Q, Shuai H, Ahooghalandari P, Gylfe E, Tengholm A (2019) Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Lancet 390 , 16641675 (2017)

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Although Gcgr is expressed at very low levels, the immunocytochemistry suggests that the protein is present in alpha cells (although below the detection level in 66% of the alpha cells)

The latter two serve as mechanoreceptors to detect gastrointestinal distension and luminal stroking 7

2.3 Role of taste receptors in the gastrointestinal hormone secretion Although, we commonly associate TRCs and TASR only to the oral cavity, they are also localized in extra-oral tissues, including the gastrointestinal tract, where they participate in energy homeostasis by modulating enteroendocrine hormone release (GLP-1, GIP, CCK, PYY) and nutrient sensing, thereby influencing gastric emptying and metabolic adjustments (e.g., glycemia) (59, 60)