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In parallel, luteolin interferes with MAPK signaling by reducing activation of ERK, JNK, and p38 kinases, key upstream amplifiers of cytokine and chemokine production ( Chemokines such as CCL2 and CCL5 play essential roles in immune cell recruitment and polarization within reproductive tissues, and their dysregulation promotes chronic inflammation, macrophage infiltration, angiogenesis, and fibrotic remodeling characteristic of endometriosis and related disorders (Li et al., 2022

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In subcategories of lipids, a substantial reduction was observed for acyl-carnitines, whereas long-chain FAs and monoacylglycerols were enriched in the kidneys of cKOt mice (Supplemental Figure 2A)